Fertility Research

Yao, H., Mo, S., Wang, J., Li, Y., Wang, C. Z., Wan, J. Y., Zhang, Z., Chen, Y., Sun, R., Yuan, C. S., Liu, X., Li, L., & Wang, Q. (2018). Genome-Wide DNA Methylation Profiles of Phlegm-Dampness Constitution.Cellular physiology and biochemistry: international journal of experimental cellular physiology, biochemistry, and pharmacology, 45(5), 1999–2008. https://doi.org/10.1159/000487976

• Specific constitution – Phlegm Damp leading to epigenetic changes – metabolic disease

Kanherkar, R. R., Stair, S. E., Bhatia-Dey, N., Mills, P. J., Chopra, D., & Csoka, A. B. (2017). Epigenetic Mechanisms of Integrative Medicine. Evidence-based complementary and alternative medicine : eCAM, 2017, 4365429. https://doi.org/10.1155/2017/4365429

• epigenetic mechanism through which integrative medicine modulates healing
• encompasses several modalities of CAM including acupuncture and herbal medicine

Kokosar, M., Benrick, A., Perfilyev, A., Nilsson, E., Källman, T., Ohlsson, C., Ling, C., & Stener-Victorin, E. (2018). A Single Bout of Electroacupuncture Remodels Epigenetic and Transcriptional Changes in Adipose Tissue in Polycystic Ovary Syndrome. Scientific reports, 8(1), 1878.https://doi.org/10.1038/s41598-017-17919-5

• great article, used Applicable here. Specific acupuncture treatment, could be reproduced.

Smith, C. A., Armour, M., Shewamene, Z., Tan, H. Y., Norman, R. J., & Johnson, N. P. (2019). Acupunctureperformed around the time of embryo transfer: a systematic review and meta-analysis. Reproductive biomedicine online, 38(3), 364–379. https://doi.org/10.1016/j.rbmo.2018.12.038

Hullender Rubin, L. E., Opsahl, M. S., Wiemer, K. E., Mist, S. D., & Caughey, A. B. (2015). Impact of whole systems traditional Chinese medicine on in-vitro fertilization outcomes. Reproductive biomedicine online, 30(6), 602–612. https://doi.org/10.1016/j.rbmo.2015.02.005

Gu, Y. E., Zhang, X., Zhang, Q., Dai, M. C., Wu, Y., Zhou, Y., & Qu, F. (2019). The effects of acupuncture on pregnancy outcomes of in vitro fertilization with embryo transfer: Aninterdisciplinary systematic review. Journal of gynecology obstetrics and human reproduction, 48(8), 677–684. https://doi.org/10.1016/j.jogoh.2019.07.008

• great data on existing studies
• explores criteria to improve on future studies

Stener-Victorin, E., Waldenström, U., Andersson, S. A., & Wikland, M. (1996). Reduction of blood flowimpedance in the uterine arteries of infertile women with electro-acupuncture. Human reproduction (Oxford, England), 11(6), 1314–1317. https://doi.org/10.1093/oxfordjournals.humrep.a019378

Stener-Victorin, E., Baghaei, F., Holm, G., Janson, P. O., Olivecrona, G., Lönn, M., & Mannerås-Holm, L. (2012). Effects of acupuncture and exercise on insulin sensitivity, adipose tissue characteristics, and markers of coagulation and fibrinolysis in women with polycystic ovary syndrome: secondaryanalyses of a randomized controlled trial. Fertility and sterility, 97(2), 501–508. https://doi.org/10.1016/j.fertnstert.2011.11.010

Manheimer E. (2011). Selecting a control for in vitro fertilization and acupuncture randomized controlled trials (RCTs): how sham controls may unnecessarily complicate the RCT evidence base. Fertility and sterility, 95(8), 2456–2461. https://doi.org/10.1016/j.fertnstert.2011.04.040

Magarelli, P. C., Cridennda, D. K., & Cohen, M. (2009). Changes in serum cortisol and prolactin associated with acupuncture during controlled ovarian hyperstimulation in women undergoing in vitro fertilization-embryo transfer treatment. Fertility and sterility, 92(6), 1870–1879. https://doi.org/10.1016/j.fertnstert.2008.10.067

Wen, Q., Hu, M., Lai, M., Li, J., Hu, Z., Quan, K., Liu, J., Liu, H., Meng, Y., Wang, S.,

Wen, X., Yu, C., Li, S., Huang, S., Zheng, Y., Lin, H., Liang, X., Lu, L., Mai, Z., Zhang, C., … Ma, H. (2021).Effect of acupuncture and metformin on insulin sensitivity in women with polycystic ovary syndrome and insulin resistance: a three-armed randomized controlled trial. Human reproduction (Oxford, England), deab272.

Advance online publication. https://doi.org/10.1093/humrep/deab272

Kim, J., Lee, H., Choi, T. Y., Kim, J. I., Kang, B. K., Lee, M. S., Joo, J. K., Lee, K. S., &

You, S. (2021). Acupuncture for Poor Ovarian Response: A Randomized Controlled Trial. Journal of clinical medicine, 10(10), 2182. https://doi.org/10.3390/jcm10102182

Manheimer, E., Zhang, G., Udoff, L., Haramati, A., Langenberg, P., Berman, B. M., & Bouter, L. M. (2008).Effects of acupuncture on rates of pregnancy and live birth among women undergoing in vitro fertilisation: systematic review and meta-analysis. BMJ (Clinical research ed.), 336(7643), 545–549. https://doi.org/10.1136/bmj.39471.430451.BE

Ng, E. H., So, W. S., Gao, J., Wong, Y. Y., & Ho, P. C. (2008). The role of acupuncture in the management of subfertility. Fertility and sterility, 90(1), 1–13. https://doi.org/10.1016/j.fertnstert.2008.02.094

Dieterle, S., Ying, G., Hatzmann, W., & Neuer, A. (2006). Effect of acupuncture on the outcome of in vitro fertilization and intracytoplasmic sperm injection: a randomized, prospective, controlled clinical study. Fertility and sterility, 85(5), 1347–1351. https://doi.org/10.1016/j.fertnstert.2005.09.062

Stener-Victorin, E., Waldenström, U., Andersson, S. A., & Wikland, M. (1996). Reduction of blood flowimpedance in the uterine arteries of infertile women with electro-acupuncture. Human reproduction (Oxford, England), 11(6), 1314–1317. https://doi.org/10.1093/oxfordjournals.humrep.a019378

So, E. W., Ng, E. H., Wong, Y. Y., Lau, E. Y., Yeung, W. S., & Ho, P. C. (2009). A randomized double blind comparison of real and placebo acupuncture in IVF treatment. Human reproduction (Oxford, England), 24(2), 341–348. https://doi.org/10.1093/humrep/den380

• Interesting study that found placebo group having a significantly higher overall pregnancy rate when compared with real acupuncture, not inert

Westergaard, L. G., Mao, Q., Krogslund, M., Sandrini, S., Lenz, S., & Grinsted, J. (2006). Acupuncture on the day of embryo transfer significantly improves the reproductive outcome in infertile women: aprospective, randomized trial. Fertility and sterility, 85(5), 1341–1346. https://doi.org/10.1016/j.fertnstert.2005.08.070

Magarelli, P. C., Cridennda, D. K., & Cohen, M. (2009). Changes in serum cortisol and prolactin associated with acupuncture during controlled ovarian hyperstimulation in women undergoing in vitro fertilization-embryo transfer treatment. Fertility and sterility, 92(6), 1870–1879. https://doi.org/10.1016/j.fertnstert.2008.10.067

Stener-Victorin, E., Jedel, E., Janson, P. O., & Sverrisdottir, Y. B. (2009).

Low-frequency electroacupuncture and physical exercise decrease high muscle sympathetic nerve activity in polycystic ovary syndrome. American journal of physiology. Regulatory, integrative and comparative physiology, 297(2), R387–R395. https://doi.org/10.1152/ajpregu.00197.2009

Stener-Victorin, E., Jedel, E., & Mannerås, L. (2008). Acupuncture in polycystic ovary syndrome: current experimental and clinical evidence. Journal of neuroendocrinology, 20(3), 290–298. https://doi.org/10.1111/j.1365-2826.2007.01634.x

Flower, A., Liu, J. P., Lewith, G., Little, P., & Li, Q. (2012). Chinese herbal medicine for endometriosis. The Cochrane database of systematic reviews, (5), CD006568. https://doi.org/10.1002/14651858.CD006568.pub3

Lian, F., Li, X. L., Sun, Z. G., Zhang, J. W., Liu, Y. H., & Ma, F. M. (2009). Effect of Quyu Jiedu granule onmicroenvironment of ova in patients with endometriosis. Chinese journal of integrative medicine, 15(1), 42–46.

https://doi.org/10.1007/s11655-009-0042-8

Huang, S. T., & Chen, A. P. (2008). Traditional Chinese medicine and infertility. Current opinion in obstetrics & gynecology, 20(3), 211–215. https://doi.org/10.1097/GCO.0b013e3282f88e22

Chen, H. Y., Lin, Y. H., Su, I. H., Chen, Y. C., Yang, S. H., & Chen, J. L. (2014).

Investigation on Chinese herbal medicine for primary dysmenorrhea: implication from a nationwide prescription database in Taiwan. Complementary therapies in medicine, 22(1), 116–125. https://doi.org/10.1016/j.ctim.2013.11.012

Ko, K. M., & Leung, H. Y. (2007). Enhancement of ATP generation capacity, antioxidant activity andimmunomodulatory activities by Chinese Yang and Yin tonifying herbs. Chinese medicine, 2, 3. https://doi.org/10.1186/1749-8546-2-3

Park, J. J., Kang, M., Shin, S., Choi, E., Kwon, S., Wee, H., Nam, B., & Kaptchuk, T. J. (2010). Unexplained infertility treated with acupuncture and herbal medicine in Korea. Journal of alternative and complementary medicine (New York, N.Y.), 16(2), 193–198. https://doi.org/10.1089/acm.2008.0600